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Nephrogenic diabetes insipidus is a kidney-related condition that causes excessive thirst and urination. webmd explains its causes, symptoms, diagnosis, and treatment.. Diabetes insipidus is a condition caused by loss of the effect of antidiuretic hormone on the collecting ducts of the kidneys, resulting in loss of free water. Forced diuresis (increased urine formation by diuretics and fluid) may enhance the excretion of certain drugs in urine and is used to treat drug overdose or poisoning.